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There is currently a .Net update that has caused disruption on SharePoint 2007,2010,2013 and 2016 platforms. 

 

After applying .NET Security Only patch to resolve CVE-2018-8421 (Remote Code Execution Vulnerability) , all SharePoint "out of the box" & Nintex Workflows fail to execute and the log will show an error like the below:

 

ULS Log: 

System.CodeDom.CodeBinaryOperatorExpression is not marked as authorized in the application configuration file

 

Publishing a Nintex workflow 

 

 

Resolution

Microsoft link to issue & resolution.

 

Microsoft related update information:

Microsoft .Net 3.5 Information.

Microsoft .Net 4.X.X information.

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