Symptoms

Is .NET Framework 4.5.2 compatible with version 4.6.6 of K2?
 

Diagnoses

Client is going to upgrade to .net 4.5.2 in their environments.
Compatibility matrix does not have documentation regarding their version of K2 Blackpearl compatibility with this version of .NET 4.5.2

 

Resolution

Found previously logged tickets with successful upgrades.

4.6.6. is compatible with .net 4.5.2

Also see below from Microsoft regarding their versions compatibility.
http://www.microsoft.com/en-za/download/details.aspx?id=42643