Symptoms
Is .NET Framework 4.5.2 compatible with version 4.6.6 of K2?
Diagnoses
Client is going to upgrade to .net 4.5.2 in their environments.
Compatibility matrix does not have documentation regarding their version of K2 Blackpearl compatibility with this version of .NET 4.5.2
Resolution
Found previously logged tickets with successful upgrades.
4.6.6. is compatible with .net 4.5.2
Also see below from Microsoft regarding their versions compatibility.
http://www.microsoft.com/en-za/download/details.aspx?id=42643