Cannot find site lookup info for request Uri http://server.ip/.

I'm getting this error on every workflow this morning in the logs. In the WF History it just says failed to start or failed to run. Last night the server was rebooted, a few updates were applied.

The sites all work fine. Everyone can submit list content and upload documents and whatnot. The only thing happening is every single workflow is failing. Whether it be new workflows, or ones that were in progress. What can I check on to look into this?