This is another type of workflow in Nintex Workflow Cloud that you could utilize, in order to build out an approval process, that goes up the chain of management. The location of the "Manager" would be from the system you're working with. In this case, it's Salesforce. But there's no reason this couldn't be Microsoft Dynamics CRM.
ce88fac46e044095bdbbff8dc39dc072- The workflow key that you can use to import the workflow in your Nintex Workflow Cloud tenant.