Hi ​@LukeR 

There isn’t a method to do this with the Update Items action.  You’d need to use a Call a SP Web Service action for it instead.  Here’s how I configured the action to get this working:

Note that in the request content the type field is the encoded internal name for the list followed by ListItem.  If you get an error in relation to this you can do a get call against the item to find this pretty easily. Then update “MyHyperLinkField” to match your field in your list and make sure you add the If-Match header.

Edit: Almost forgot I hardcoded the Item ID in the URL but you can replace that with the Item Id for the item to update.

Thanks, Brent! I was hoping there was a method that I was just missing instead of having to fall back to the web services action. But this will work. :)

Hi ​@LukeR,

Under the covers, Nintex is just using webservices to update the SharePoint list.
If you want to use an update items action then update the column with: 

http://, 

Make sure there is a space after the comma.
This will clear the column in modern view. The column will not be clickable.
If you edit the column in Grid view, it will show http://. Unfortunately, due to URL validation, there is no way around not adding this.
In classic view, the column will show http:// and be clickable.