Hi Evan! You shouldn’t need to make many changes, if any - do you know if you’ll be able to test in a sandbox first? If you have any navigation based on hardcoded URLs with the instance name, you may need to change it (I would recommend using relative URLs anyways). 

Thanks for the quick replay Matt. We’ve got Skuid in some sandboxes as well, so we’ll be sure to test there as well.

Thanks!