In order to do this you would have to tie into the APEX Send Email capabilities.  We have not actually done this, but with enough coding, it should be possible. 

https://developer.salesforce.com/docs/atlas.en-us.apexcode.meta/apexcode/apex_forcecom_email_outboun…

I am good with the triggering of the email (I have a declarative work-around for this that triggers a Salesforce workflow) but I am trying to customize the look and feel of the email that the user receives.  Instead of building a Visualforce email template that has merge fields from an object, then a html table component of child records, I want to have a Visualforce email template that displays a Skuid page!  I imagine I’d have to use the messaging tags - but I was hoping to replace the body section with a Skuid page reference.  That way I can control the look and take advantage of my cool new theme.

This is the thread I was looking at:
https://developer.salesforce.com/docs/atlas.en-us.pages.meta/pages/pages_email_templates_creating.ht…

I had the same question as Chandra. I can send emails via apex, but is it possible to use skuid as the template like you would with visualforce? I haven’t even attempted to do it, but I’m curious if anyone has?

Same here, in case anyone ever figured it out. I get request of this sort on a weekly basis…