Check out this fiddle: http://jsfiddle.net/qoyngj0a/ . You can do the popup with a Skuid template with some HTML. You need .

The tricky part is accessing salesforce’s popup. The image is stored in a special location in salesforce. ie. https://c.ap1.content.force.com/profilephoto/72990000000RWjN/F 

Not even sure I can edit this without doing so from the standard popup shown in the video.

I know for sure that you won’t be able to use the Skuid file uploader utility to update the profile pic.  That has been on our to do list for a while and it isn’t delivered. 

just wondering if Skuid is planning to include that feature soon?