Symptoms
While accessing K2 Worklist webpart or the K2 app settings, you receive the following error message:
The file '/Designer/Runtime/_trust/spauthorize.aspx' does not exist.
The same error message appears while accessing the K2 list settings (SP list > K2 icon on ribbon).
Diagnoses
Redirecting to the wrong URL
Cannot find a default Runtime/runtime URL
This is a known issue as documented in K2 for SharePoint 1.0 (4.13350.1.0) Known Issues List
Resolution
Follow the steps from KB mentioned above you can resolve this issue after completing the registration wizard and changing the Designtime to Runtime.