if you mean with permission group a sharepoint group, the yes it's possible.

use fn-IsMemberOfGroup() inline function.

it's not however directly available in rule's formula builder, but you can first build formula somewhere aside where inline functions are available and then copy it over to rule's formula

see https://community.nintex.com/message/36494?commentID=36494#comment-36494 

I set this condition in the control's Settings-> Appearance->Enabled area of the and it works fine if you are making the condition based on a single role .

What if I want to enable based on if user is a member of Role A or Role B?.

It does not seem to work. I have also tried the same expression in a Format Rule.

fn-Or(fn-IsMemberOfGroup("Requirements Author"),fn-IsMemberOfGroup("Test Managers"))