I guess the simplest way to ask this is: Is there a way to validate a text input from a list lookup?
I am using javascript to autofill a textbox instead of using a dropdown with 1400 entries without cascading being an option.
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from your short description I'm not sure what exactly you would like to achieve.
but have a look on lookup() function.
I think following seems to be similar to what you ask for https://community.nintex.com/message/60637-re-validate-a-field-in-nintex-with-a-custom-list-on-sp2013?commentID=60637#co…
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