I encountered this error when installing a 64 bit version of K2Blackpearl and pointing to an existing set of databases the error would repeat every 30 seconds or so in console mode, this is what showed up in the host log:
"22200","2008-11-12 10:06:03","Error","General","28039","CouldNotConnect","K2ClusterServer.CheckRunning","28039 Could not connect to [OldServerName]","anonymous","0.0.0.0","[NewServerName]:C:Program Files (x86)K2 blackpearlHost ServerBin","22200","661efcc16669467c8dd1c5bb72ffcdac",""
The solution was to go into the K2Server database, open up the _Server table and locate any reference made to the old BlackPearl server (in my case the 32 bit server) Once that record was removed from the table the problem disappeared.