The easiest option would be to have the inbound email address be a SharePoint library then have K2 kick off a workflow when there is a new item inserted based on that email.  However there are other options.  But not as easy.  I think you would have to write something custom here that plugs into your email provider to monitor for new messages.   I know this has been done with K2 previously so it is possible at least with exchange.

Anyone else tried to do something like this?

Hi ,

Thanks for the answer.. i really appreciate ..

the only problem with this solution is that K2 will start 2 processes if there is an attachment in the email ..

Another option, You can write a window service that read mail box periodically and use K2 object model to start workflow.