Symptoms
The following error is being thrown when trying to create a workflow:
The error message is: Could not find a part of the path 'C:Program FilesReference AssembliesMicrosoftFrameworkv4. 6'.
Diagnoses
This error is related to having Framework .Net 4.6 installed, which K2 does not support at this time.
http://help.k2.com/blackpearl/support-matrix#NET
Resolution
Uninstalling the Framework .Net 4.6 update will resolve this issue.