Issue
Does Nintex support SharePoint Farms that use two different domains?
Resolution
Nintex workflows will not be directly affected by two domains in a single farm.
Interactions with other parts of SharePoint; such as User Permissions, or access to the User Profile Service by the underlying SharePoint system, maybe effected.
Best way to avoid issues with User Permissions, or the User Profile Service is to verify that there is a two-way trust between the domains, which should alleviate any potential issues in regards to Nintex Workflows
Additional Information
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