This is for Nintex Workflow 2010.
USE CASE: Customer wants a document library. Customer wants e-mail notification when documents are added or modified in specific subfolders and nested subfolders within the library. Depending on the subfolder, additional workflow actions may need to be taken.
Can this be done with NW2010?
Question - Is your folder structure already created? or users can give any names to the folders and create new?
The issue with this kind of workflow is to identify the folder name and if it is a root or sub-folder. If you know the folder structure already, then you can create workflow variables with links to the folders and sub folders. Identify if the path to the document contains this structure. If it does, then you know where the document is.
If the assumption is incorrect, i'm not sure if you can manage the irregularities in folder structures with workflow. Though the item added and modified workflow will work, but it may not tell which folder it is going in.