Does Nintex for O365 have the User Profile Lookup? I have been searching and not finding. If there isn't such a thing in O365, is there a workaround for this?
What are you trying to look up? The Office 365 Query User Profile action can be used. It is also possible to leverage the Microsoft Graph API: Graph Explorer - Microsoft Graph
I want to be able to have the system enter a person's department and their manager pulling information from our Active Directory system. I will check the other items you mentioned.
Forms now have the UserProfileLookup Function and the workflow tool also has the Query User Profile action as well. Both of these should cover you on what you need.