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Nintex Newbie

Unable to Save or publish workflow Ntx2010

I'm not able to save or publish any workflows - existing or new. It is not giving me an error, it is not giving the pop-up message to confirm saving. I tried different browsers. I mainly use IE (it is Sp/Ntx 2010). I tried restarting. 

Wf subscription and limits are fine.. 

The issue is not similar to this: 

Any hints or what to look for?

update: I think the issue might be related to windows 10 IE. working with Nintex support to figure out the problem.

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