I have found the best practices for O365 Nintex workflow https://community.nintex.com/t5/Best-Practices/Nintex-Workflow-Office-365-Best-Practices/ta-p/85923.
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Hi @devendra14321, while there is not a 'Best Practices' document for NWC the same way there is for workflow for O365, I would recommend checking out the Product Documentation as it gives some guidelines around how to build workflows if you're just getting started. Also regarding your questions: