We just upgraded to use Exchange 2007 SMTP over the weekend, it is running fine for other emails but I did get 2 random errors below when sending SMTP email:
This was fine with Exchange 2003. Anyway the issue is random and repair it works fine, just wondering if you've came across this. I searched Google but didn't find any definitive answer.
'This is with .NET 2.0's SMTP client. Default timeout is 100 seconds.
http://msdn.microsoft.com/en-us/library/system.net.mail.smtpclient.timeout%28VS.80%29.aspx
Dim objMsg As New System.Net.Mail.MailMessage
Dim objSender As New System.Net.Mail.SmtpClient
Service not available, closing transmission channel. The server response was: 4.4.1 Connection timed out